Table 3. Comparison of macular and nerve choroidal thickness among chronic LHON patients, DOA patients and the control group.
| Chronic LHON patients | DOA patients | Control group | Chronic LHON patients vs Control group | DOA patients vs Control group | Chronic LHON patients vs DOA patients | |
|---|---|---|---|---|---|---|
| Average macular choroidal thickness (μm) | 259.8 ± 67.9 | 250.9 ± 83.4 | 309.5 ± 38.2 | p = 0.002** | p < 0.0001** | p = 1.0 |
| Macular choroidal SF thickness (μm) | 274.9 ± 77.3 | 254.4 ± 85.2 | 344.1 ± 49.1 | p < 0.0001** | p < 0.0001** | p = 0.618 |
| Macular choroidal 1500 mμ N thickness (μm) | 217.4 ± 73.0 | 212.9 ± 95.8 | 256.6 ± 59.2 | p = 0.084 | p = 0.032* | p = 1.0 |
| Macular choroidal 750 mμ N thickness (μm) | 252.4 ± 76.8 | 237.0 ± 85.9 | 309.2 ± 57.4 | p = 0.030* | p < 0.0001** | p = 1.0 |
| Macular choroidal 1500 mμ S thickness (μm) | 260.5 ± 71.3 | 268.9 ± 79.5 | 317.6 ± 42.9 | p = 0.001** | p = 0.003** | p = 1.0 |
| Macular choroidal 750 mμ S thickness (μm) | 262.8 ± 77.4 | 261.6 ± 80.81 | 318.2 ± 44.2 | p = 0.002** | p = 0.001** | p = 1.0 |
| Macular choroidal 1500 mμ T thickness (μm) | 257.3 ± 70.5 | 254.9 ± 80.6 | 300.1 ± 51.3 | p = 0.020* | p = 0.008* | p = 1.0 |
| Macular choroidal 750 mμ T thickness (μm) | 270.4 ± 73.4 | 257.1 ± 82.6 | 322.3 ± 44.3 | p = 0.030* | p < 0.0001** | p = 1.0 |
| Macular choroidal 1500 mμ I thickness (μm) | 274.3 ± 69.4 | 260.4 ± 80.5 | 303.9 ± 40.3 | p = 0.143 | p = 0.008** | p = 1.0 |
| Macular choroidal 750 mμ I thickness (μm) | 267.9 ± 68.2 | 255.8 ± 83.4 | 313.4 ± 43.7 | p = 0.001** | p = 0.015* | p = 1.0 |
| Average nerve choroidal thickness (μm) | 157.4 ± 61.0 | 144.8 ± 61.0 | 167.9 ± 37.5 | p = 1.0 | p = 0.160 | p = 0.874 |
| Nerve choroidal T thickness (μm) | 165.1 ± 70.0 | 147.6 ± 72.5 | 180.1 ± 37.9 | p = 0.918 | p = 0.070 | p = 0.689 |
| Nerve choroidal S thickness (μm) | 172.8 ± 71.0 | 158.2 ± 66.5 | 182.3 ± 48.2 | p = 1.0 | p = 0.291 | p = 0.940 |
| Nerve choroidal N thickness (μm) | 156.5 ± 69.9 | 150.7 ± 51.7 | 175.2 ± 51.3 | p = 0.521 | p = 0.177 | p = 1.0 |
| Nerve choroidal I thickness (μm) | 135.2 ± 56.8 | 123.0 ± 52.9 | 133.3 ± 41.0 | p = 1.0 | p = 1.0 | p = 0.900 |
LHON: Leber Hereditary Optic Neuropathy; DOA: Dominant Optic Atrophy; SF: sub-foveal; T: temporal quadrant; S: superior quadrant; N: nasal quadrant; I: inferior quadrant.
Data are showed as mean ± SD. Values were compared between each LHON group and healthy subjects, by means of one-way analysis of covariance (ANCOVA), followed by Bonferroni post hoc test. Gender was used as covariate in the analysis.
*<0.05, **<0.01.