Table 4. Comparison of Retinal Nerve Fiber Layer thickness between LHON patients and the control group.
| Acute LHON patients | Carrier LHON patients | Control group | Acute LHON patients vs Control group | Carrier LHON patients vs Control group | Acute LHON patients vs Carrier LHON patients | |
|---|---|---|---|---|---|---|
| RNFL Average thickness (μm) | 121.7 ± 33.1 | 109.7 ± 10.1 | 99.9 ± 6.6 | p = 0.002** | p = 0.038* | p = 0.001** |
| RNFL T thickness (μm) | 64.7 ± 19.3 | 83.4 ± 15.3 | 67.38 ± 10.6 | p = 1.0 | p < 0.0001** | p = 0.001** |
| RNFL S thickness (μm) | 169.9 ± 33.4 | 131.5 ± 14.6 | 129.3 ± 16.1 | p < 0.0001** | p = 1.0 | p < 0.0001** |
| RNFL N thickness (μm) | 95.2 ± 13.5 | 82.7 ± 20.1 | 79.0 ± 16.6 | p = 0.061 | p = 1.0 | p = 0.190 |
| RNFL I thickness (μm) | 158.1 ± 16.4 | 144.1 ± 20.5 | 123.7 ± 10.6 | p < 0.0001** | p < 0.0001** | p = 0.018* |
LHON: Leber Hereditary Optic Neuropathy; RNFL: Retinal Nerve Fiber Layer; SF: sub-foveal; T: temporal quadrant; S: superior quadrant; N: nasal quadrant; I: inferior quadrant.
Data are showed as mean ± SD. Values were compared between each LHON group and healthy subjects, by means of one-way analysis of covariance (ANCOVA), followed by Bonferroni post hoc test. Gender was used as covariate in the analysis.
*<0.05, **<0.01.