Table 1. Effects of compounds 3a and 3f on the biochemical parameters of normal and diabetic rats.
Biochemical Parameter | Normal Control | Diabetic Control | Pioglitazone 15 mg/kg | Compound 3a 15 mg/kg | Compound 3f 15 mg/kg |
---|---|---|---|---|---|
FFA (mmol/L) | 0.16 ± 0.03 | 0.21 ± 0.01a | 0.15 ± 0.01b | 0.17 ± 0.03b | 0.16 ± 0.02b |
HDL-c (mmol/L) | 0.83 ± 0.01 | 0.61 ± 0.16a | 0.72 ± 0.15b | 0.64 ± 0.09 | 0.66 ± 0.12b |
LDL-c (mmol/L) | 0.24 ± 0.03 | 2.92 ± 1.13a | 1.60 ± 0.14b | 1.35 ± 0.25b | 1.17 ± 0.43b |
TC (mmol/L) | 1.53 ± 0.18 | 8.91 ± 3.44a | 5.20 ± 1.25b | 4.71 ± 0.51b | 3.81 ± 1.23b |
TG (mmol/L) | 0.71 ± 0.05 | 1.18 ± 0.21a | 0.66 ± 0.23b | 0.68 ± 0.21b | 0.49 ± 0.23b |
All values are expressed as the means ± SD. The level of significance was determined by one-way ANOVA, followed by the Bonferroni post hoc test. aP < 0.01 versus the normal control. bP < 0.05 versus the diabetic control.