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. 2016 Nov 17;6:37261. doi: 10.1038/srep37261

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Copyright © 2016, The Author(s)

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(a): Schedule of treatment and behavioral tests. Saline or poly(I:C)(5 mg/kg/day from E12 to E17) was injected into pregnant mice. Vehicle or D-serine (600 mg/L) in drinking water was given into mice from 4-week to 8-week olds. Behavioral tests including locomotion (LMT: 10 W (D1)) and novel object recognition test (NORT: D6 and D7) were performed. (b): Locomotion: there was no significant difference among the four groups in the locomotor activity. The value is expressed as the mean ± SEM (n = 10–15). N.S.: not significant. (c): NORT: The exploratory preferences were significantly lower in the poly(I:C) offspring than controls in the retention session, but there was no difference between the two groups in the training session. ***P < 0.001 compared with control group. The value is expressed as the mean ± SEM (n = 9–13).