Figure 2. Intrathecal (i.t.) administration of GAS depressed mechanical and thermal pain hypersensitivity induced by unilateral CFA inflammation.

(A) Representative traces showing the attenuation of CFA-induced mechanical pain hypersensitivity by a single bolus of i.t. GAS (10 mM) at different time points after GAS administration. (B) Quantitative analysis showing that i.t. GAS increased the response threshold to mechanical stimuli compared to vehicle treatment (n = 8, P < 0.05). (C) Quantitative summary showing the depression of thermal hyperalgesia by i.t. GAS (n = 8, P < 0.05). All data are represented as mean ± S.E.M. *P < 0.05.