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. 2016 Nov 17;6:37225. doi: 10.1038/srep37225

Figure 4. Exogenous IFNα enhances susceptibility of productively infected T cells to ADCC mediated by bNAbs.

Figure 4

Parental CEM CD4+ T cells were infected or not (mock) with CCR5-tropic NL4.3.ADA.IRES.GFP WT virus for 20 h and then exposed (IFN) or not (UT) to IFNα for about 48 h. Infected cells were analyzed for BST2 or Env expression using (a) anti-BST2 or (b) the indicated anti-Env Abs, respectively. (c and d) Cell susceptibility to ADCC was examined as described in Fig. 1 legend. Panel c shows ADCC activities at different concentrations of Abs (in µg/ml) of 2 donors as examples. Panel d summarizes mean target cell killing mediated PGT126 from multiple donors. Each dot represents one PBMC donor. In this Panel, Mann-Whitney U-tests were used to compare ranks between UT and IFN-treated groups.