Figure 2. Cinaciguat normalises increased contractility in pressure overload.

Baseline characteristics of pressure-volume relations did not differ in the AABCo and AABCin groups (a). P-V loops recorded during occlusion of the inferior caval vein (b) and the load independent indices of contractility derived from these measurements (c) show, however, that Cinaciguat significantly decreased the increase in contractility following abdominal aortic banding. PRSW: preload recruitable stroke work; E_es: end systolic elastance; dP/dt_max-EDV: maximum rate of pressure change – end diastolic volume relationship; p_int: interaction p value *p < 0.05 vs. ShamCo; ^#p < 0.05 vs. AABCo.