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. 2016 Nov 17;6:37166. doi: 10.1038/srep37166

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Differences between the groups are illustrated in representative photomicrographs of left ventricular (LV) myocardial sections with haematoxylin-eosin (a) and Picrosirius red staining (b), TUNEL (c) and cGMP immunohistochemistry (d). Average cardiomyocyte diameter (e) and collagen area of subendocardial LV myocardium (f) was significantly elevated in the AABCo group compared to ShamCo, both of which alterations were significantly decreased following Cinaciguat treatment. TUNEL staining revealed a significant increase in the number of apoptotic cell nuclei in the AABCo group compared to ShamCo and AABCin (g). cGMP score (h) was significantly higher in the AABCin group than in the AABCo animals. p_int: interaction p value *p < 0.05 vs. ShamCo; ^#p < 0.05 vs. AABCo.