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. 2016 Nov 17;6:37166. doi: 10.1038/srep37166

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Copyright © 2016, The Author(s)

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The strong sGC activating effect of Cinaciguat during pathologic conditions was confirmed by measuring plasma level of cGMP, which was significantly elevated in AABCin rats. cGMP activates PKG, which then phosphorylates VASP and Pln, phosphorylation ratio of which are widely used markers of PKG activity. Both of these were markedly increased despite the unchanged amount of PKG in the AABCin group, indicating increased PKG activity in these animals. Representative Western blot bands are shown for each group and investigated protein on the right. PKG: protein kinase G; Pln: phospholamban; VASP: vasodilator stimulated phosphoprotein; p_int: interaction p value *p < 0.05 vs. ShamCo; ^#p < 0.05 vs. AABCo.