Table 2. Baseline hemodynamic parameters.
| ShamCo | ShamCin | AABCo | AABCin | pband | ptreat | pint | |
|---|---|---|---|---|---|---|---|
| HR (1/min) | 433 ± 15 | 412 ± 17 | 435 ± 11 | 444 ± 17 | 0.255 | 0.679 | 0.309 |
| MAP (mmHg) | 134 ± 5 | 127 ± 5 | 183 ± 7* | 177 ± 5* | <0.0001 | 0.218 | 0.902 |
| ESV (μl) | 103 ± 8 | 91 ± 8 | 97 ± 7 | 96 ± 8 | 0.959 | 0.400 | 0.436 |
| EDV (μl) | 221 ± 19 | 190 ± 13 | 233 ± 11 | 199 ± 16 | 0.790 | 0.094 | 0.728 |
| LVESP (mmHg) | 140 ± 4 | 138 ± 3 | 191 ± 14* | 185 ± 6* | <0.0001 | 0.610 | 0.903 |
| LVEDP (mmHg) | 4.7 ± 0.5 | 4.1 ± 0.4 | 4.5 ± 0.3 | 4.9 ± 0.6 | 0.248 | 0.741 | 0.484 |
| SV (μl) | 145 ± 14 | 128 ± 7 | 156 ± 10 | 135 ± 7 | 0.390 | 0.066 | 0.857 |
| EF (%) | 60 ± 1 | 61 ± 2 | 61 ± 1 | 61 ± 1 | 0.489 | 0.685 | 0.854 |
| CO (ml/min) | 63.3 ± 6.7 | 52.4 ± 3.1 | 67.6 ± 4.6 | 56.5 ± 1.8 | 0.373 | 0.025 | 0.984 |
| SW (mmHg*μl) | 16.49 ± 1.76 | 14.29 ± 1.19 | 20.92 ± 1.64 | 17.67 ± 1.40 | 0.017 | 0.088 | 0.736 |
| Ea (mmHg/μl) | 1.03 ± 0.10 | 1.06 ± 0.07 | 1.28 ± 0.13 | 1.39 ± 0.07 | 0.008 | 0.479 | 0.668 |
| τG (ms) | 11.21 ± 0.49 | 11.33 ± 0.75 | 16.30 ± 1.65* | 13.65 ± 0.66 | 0.001 | 0.225 | 0.185 |
| dP/dtmax (mmHg/s) | 8589 ± 460 | 8200 ± 543 | 10999 ± 430* | 10374 ± 648 | 0.0001 | 0.338 | 0.822 |
HR: heart rate; ESV: end-systolic volume, EDV: end diastolic volume; LVSP: left ventricular systolic pressure, LVEDP: left ventricular end diastolic pressure; MAP: mean arterial pressure; SV: stroke volume; EF: ejection fraction; CO: cardiac output; SW: stroke work; Ea: arterial elastance; τG: time constant of active relaxation according to Glantz (tau); dP/dtmax: maximum rate of pressure change; pband: p value of ‘aortic banding’ main effect; ptreat: p value of ‘Cinaciguat treatment’ main effect; pint: interaction p value *p < 0.05 vs. ShamCo; #p < 0.05 vs. AABCo.