Table 2. Prevalence of genotype frequencies in the Jing and Han populations [n (%)].
| Mutation | Genotype | Jing (n = 1272) | Han (n = 1280) | X2 | P-value |
|---|---|---|---|---|---|
| AGBL4 rs320017 A > G | AA | 768(60.38) | 836(65.31) | 6.704 | 0.035 |
| AG | 438(34.43) | 388(30.31) | |||
| GG | 66(5.19) | 56(4.38) | |||
| PHWE | 0.730 | 0.202 | |||
| AGBL4 rs320018 A > G | AA | 762(59.90) | 827(64.61) | 6.137 | 0.046 |
| AG | 443(34.83) | 397(31.01) | |||
| GG | 67(5.27) | 56(4.82) | |||
| PHWE | 0.802 | 0.344 | |||
| AGBL4 rs320019 G > A | GG | 769(60.46) | 834(65.16) | 6.054 | 0.048 |
| AG | 438(34.43) | 387(30.23) | |||
| AA | 65(5.11) | 59(4.61) | |||
| PHWE | 0.797 | 0.105 | |||
| LRP8 rs6694764 G > A | GG | 405(31.84) | 465(36.33) | 6.657 | 0.036 |
| AG | 632(49.69) | 611(47.73) | |||
| AA | 235(18.47) | 204(15.94) | |||
| PHWE | 0.674 | 0.889 | |||
| LRP8 rs1288519 A > C | AA | 425(33.41) | 484(37.81) | 6.270 | 0.043 |
| AC | 618(48.59) | 597(46.64) | |||
| CC | 229(18.00) | 199(15.55) | |||
| PHWE | 0.868 | 0.507 | |||
| LRP8 rs872315 G > A | GG | 1180(92.77) | 1224(95.63) | 9.588 | 0.008 |
| AG | 88(6.92) | 54(4.21) | |||
| AA | 4(0.31) | 2(0.16) | |||
| PHWE | 0.091 | 0.090 | |||
| LRP8 rs1288520 C > T | CC | 431(33.88) | 502(39.22) | 10.453 | 0.005 |
| CT | 590(46.38) | 574(44.84) | |||
| TT | 251(19.74) | 204(15.94) | |||
| PHWE | 0.057 | 0.064 | |||
| LRP8 rs1288521 C > T | CC | 490(38.52) | 554(43.28) | 6.169 | 0.046 |
| CT | 587(46.15) | 552(43.13) | |||
| TT | 195(15.33) | 174(13.59) | |||
| PHWE | 0.356 | 0.053 | |||
| PCSK9 rs533375 C > T | CC | 886(69.65) | 963(75.23) | 10.534 | 0.005 |
| CT | 340(26.73) | 285(22.27) | |||
| TT | 46(3.62) | 32(2.50) | |||
| PHWE | 0.064 | 0.051 | |||
| PCSK9 rs584626 A > G | AA | 1116(87.74) | 1162(90.78) | 6.649 | 0.036 |
| AG | 148(11.63) | 114(8.91) | |||
| GG | 8(0.63) | 4(0.31) | |||
| PHWE | 0.207 | 0.501 | |||
| PCSK9 rs585131 A > G | AA | 1118(87.89) | 1172(91.56) | 9.332 | 0.009 |
| AG | 150(11.79) | 105(8.20) | |||
| GG | 4(0.32) | 3(0.23) | |||
| PHWE | 0.663 | 0.689 | |||
| PCSK9 rs540796 G > A | GG | 1092(85.85) | 1159(90.55) | 15.222 | 4.949E-04 |
| AG | 172(13.52) | 119(9.30) | |||
| AA | 8(0.63) | 2(0.15) | |||
| PHWE | 0.666 | 0.560 |
AGBL4, the ATP/GTP binding protein-like 4 gene; LRP8, the LDL receptor related protein 8 gene; PCSK9, the Proprotein convertase subtilisin/kexin type 9 gene; HWE, Hardy-Weinberg equilibrium.