Table 4. Prevalence of haplotype frequencies in the Jing and Han populations [n (frequency)].
| Haplotype | Jing | Han | X2 | P-value | Odds Ratio [95%CI] |
|---|---|---|---|---|---|
| AGBL4 A-A-A | 0.00(0.000) | 4.95(0.002) | 4.927 | 0.026456 | — |
| AGBL4 A-A-G | 1948.87(0.766) | 2030.84(0.793) | 5.509 | 0.018941 | 0.853 [0.747~0.974] |
| AGBL4 A-G-A | 24.62(0.010) | 24.21(0.009) | 0.007 | 0.935631 | 1.023 [0.582~1.798] |
| AGBL4 G-A-A | 5.12(0.002) | 3.15(0.001) | 0.481 | 0.487924 | 1.636 [0.402~6.663] |
| AGBL4 G-A-G | 13.01(0.005) | 12.06(0.005) | 0.043 | 0.836051 | 1.086 [0.495~2.383] |
| AGBL4 G-G-A | 538.26(0.212) | 472.69(0.185) | 5.830 | 0.015777 | 1.185 [1.032~1.360] |
| AGBL4 G-G-G | 13.60(0.005) | 12.10(0.005) | 0.098 | 0.754777 | 1.132 [0.521~2.460] |
| AGBL4 A-G-G | 0.51(0.000) | 0.00(0.000) | 0.517 | 0.472063 | — |
| LRP8 A-A-G-C-C | 13.00(0.005) | 24.19(0.009) | 3.322 | 0.068348 | 0.538 [0.274~1.059] |
| LRP8 A-A-G-T-C | 3.03(0.001) | 12.06(0.005) | 5.361 | 0.020611 | 0.252 [0.071~0.889] |
| LRP8 A-C-A-T-T | 88.00(0.035) | 54.00(0.021) | 8.594 | 0.003384 | 1.663 [1.180~2.344] |
| LRP8 A-C-G-C-C | 12.08(0.005) | 12.01(0.005) | 0.001 | 0.975872 | 1.012 [0.455~2.254] |
| LRP8 A-C-G-C-T | 0.00(0.000) | 0.80(0.000) | 0.791 | 0.373701 | — |
| LRP8 A-C-G-T-C | 96.89(0.038) | 84.86(0.033) | 0.906 | 0.341247 | 1.155 [0.858~1.554] |
| LRP8 A-C-G-T-T | 879.03(0.346) | 831.08(0.325) | 2.499 | 0.113912 | 1.098 [0.978~1.234] |
| LRP8 G-A-A-C-C | 8.00(0.003) | 4.00(0.002) | 1.361 | 0.243302 | 2.015 [0.606~6.700] |
| LRP8 G-A-G-C-C | 1417.91(0.557) | 1522.66(0.595) | 7.322 | 0.006827 | 0.858 [0.768~0.959] |
| LRP8 G-A-G-C-T | 0.00(0.000) | 2.09(0.001) | 2.074 | 0.149794 | — |
| LRP8 G-C-G-C-C | 0.00(0.000) | 0.22(0.000) | 0.219 | 0.639983 | — |
| LRP8 G-C-G-C-T | 0.00(0.000) | 12.03(0.005) | 11.985 | 0.000540 | — |
| LRP8 A-A-G-C-T | 1.01(0.000) | 0.00(0.000) | 1.014 | 0.313942 | — |
| LRP8 A-A-G-T-T | 8.96(0.004) | 0.00(0.000) | 9.032 | 0.002663 | — |
| LRP8 G-A-G-T-C | 16.09(0.006) | 0.00(0.000) | 16.243 | 5.63e-005 | — |
| PCSK9 C-A-A-A | 9.15(0.004) | 3.01(0.001) | 3.150 | 0.075953 | 3.069 [0.833~11.303] |
| PCSK9 C-A-A-G | 2086.39(0.820) | 2191.61(0.856) | 12.173 | 0.000488 | 0.766 [0.660~0.890] |
| PCSK9 C-A-G-A | 0.00(0.000) | 8.02(0.003) | 7.978 | 0.004749 | — |
| PCSK9 C-G-A-A | 8.01(0.003) | 0.51(0.000) | 5.953 | 0.014713 | 15.703 [2.003~123.131] |
| PCSK9 C-G-A-G | 0.00(0.000) | 0.54(0.000) | 0.539 | 0.462699 | — |
| PCSK9 C-G-G-A | 4.42(0.002) | 3.86(0.002) | 0.042 | 0.836807 | 1.154 [0.294~4.528] |
| PCSK9 C-G-G-G | 4.03(0.002) | 3.46(0.001) | 0.048 | 0.827146 | 1.173 [0.279~4.941] |
| PCSK9 T-A-A-G | 259.47(0.102) | 235.37(0.092) | 1.472 | 0.224998 | 1.122 [0.932~1.351] |
| PCSK9 T-G-A-A | 0.00(0.000) | 11.93(0.005) | 11.888 | 0.000569 | — |
| PCSK9 T-G-A-G | 0.00(0.000) | 6.02(0.002) | 5.993 | 0.014383 | — |
| PCSK9 T-G-G-A | 143.43(0.056) | 95.67(0.037) | 10.327 | 0.001317 | 1.539 [1.181~2.006] |
| PCSK9 T-A-A-A | 22.99(0.009) | 0.00(0.000) | 23.237 | 1.46e-006 | — |
| PCSK9 T-A-G-G | 2.00(0.001) | 0.00(0.000) | 2.018 | 0.155421 | — |
| PCSK9 T-G-G-G | 4.10(0.002) | 0.00(0.000) | 4.133 | 0.042083 | — |
AGBL4, the ATP/GTP binding protein-like 4 gene; LRP8, the LDL receptor related protein 8 gene; PCSK9, the Proprotein convertase subtilisin/kexin type 9 gene.