Table 5. Prevalence of G × G interaction frequencies in the Jing and Han populations [n (frequency)].
| G × G interactions | Jing | Han | X2 | P-value | Odds Ratio[95%CI] | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A | B | C | D | E | F | G | H | I | J | K | L | |||||
| A | A | G | A | A | G | C | C | C | A | A | G | 13.00(0.005) | 24.20(0.009) | 3.325 | 0.068240 | 1.858 [0.945~3.653] |
| A | A | G | A | A | G | C | T | C | A | A | G | 1.01(0.000) | 0.00(0.000) | 1.014 | 0.313942 | — |
| A | A | G | A | A | G | T | C | C | A | A | G | 4.00(0.002) | 12.07(0.005) | 4.015 | 0.045102 | 3.009 [0.970~9.340] |
| A | A | G | A | A | G | T | T | C | A | A | G | 7.99(0.003) | 0.00(0.000) | 8.054 | 0.004555 | — |
| A | A | G | A | G | G | C | C | C | A | A | G | 12.09(0.005) | 12.00(0.005) | 0.001 | 0.973787 | 0.987 [0.443~2.197] |
| A | A | G | A | C | G | T | C | C | A | A | G | 95.90(0.038) | 84.09(0.033) | 0.882 | 0.347570 | 0.867 [0.643~1.168] |
| A | A | G | A | C | G | T | T | C | A | A | G | 369.92(0.145) | 356.86(0.139) | 0.377 | 0.539053 | 0.952 [0.814~1.114] |
| A | A | G | A | C | G | T | T | T | A | A | G | 3.08(0.001) | 0.00(0.000) | 3.097 | 0.078447 | — |
| A | A | G | G | A | A | C | C | C | G | G | A | 4.00(0.002) | 2.00(0.001) | 0.680 | 0.409551 | 0.496 [0.091~2.713] |
| A | A | G | G | A | A | C | C | C | G | G | G | 4.00(0.002) | 2.00(0.001) | 0.680 | 0.409551 | 0.496 [0.091~2.713] |
| A | A | G | G | A | G | C | C | C | A | A | A | 8.00(0.003) | 3.00(0.001) | 2.309 | 0.128579 | 0.372 [0.099~1.403] |
| A | A | G | G | A | G | C | C | C | A | A | G | 1401.90(0.551) | 1507.63(0.589) | 7.460 | 0.006325 | 1.167 [1.045~1.304] |
| A | A | G | G | A | G | C | C | C | G | A | A | 8.00(0.003) | 0.50(0.000) | 5.982 | 0.014474 | 0.062 [0.008~0.492] |
| A | A | G | G | A | G | T | C | C | A | A | G | 16.10(0.006) | 0.00(0.000) | 16.248 | 5.61e-005 | — |
| A | G | A | A | C | A | T | T | T | G | G | A | 12.01(0.005) | 12.00(0.005) | 0.000 | 0.985825 | 0.993 [0.445~2.214] |
| A | G | A | A | C | G | T | T | T | A | A | G | 12.00(0.005) | 12.10(0.005) | 0.000 | 0.996678 | 1.002 [0.450~2.230] |
| A | G | G | A | C | G | T | T | T | A | A | G | 1.00(0.000) | 0.00(0.000) | 1.006 | 0.315782 | — |
| G | A | A | A | C | G | T | T | C | A | A | G | 5.00(0.002) | 3.10(0.001) | 0.459 | 0.498128 | 0.616 [0.149~2.541] |
| G | A | G | A | C | A | T | T | T | G | G | A | 11.29(0.004) | 0.00(0.000) | 11.389 | 0.000743 | — |
| G | A | G | A | C | G | T | T | C | A | A | G | 1.72(0.001) | 0.00(0.000) | 1.734 | 0.187919 | — |
| G | G | A | A | C | A | T | T | T | G | G | A | 60.53(0.024) | 36.00(0.014) | 6.513 | 0.010727 | 0.585 [0.386~0.887] |
| G | G | A | A | C | A | T | T | T | G | G | G | 4.16(0.002) | 0.00(0.000) | 4.194 | 0.040582 | — |
| G | G | A | A | C | G | T | T | C | A | A | G | 147.37(0.058) | 160.01(0.063) | 0.472 | 0.492153 | 1.084 [0.861~1.366] |
| G | G | A | A | C | G | T | T | T | A | A | A | 24.16(0.009) | 0.00(0.000) | 24.431 | 7.84e-007 | — |
| G | G | A | A | C | G | T | T | T | A | A | G | 241.74(0.095) | 222.87(0.087) | 0.979 | 0.322457 | 0.908 [0.750~1.099] |
| G | G | A | A | C | G | T | T | T | A | G | G | 1.00(0.000) | 0.00(0.000) | 1.006 | 0.315782 | — |
| G | G | A | A | C | G | T | T | T | G | G | A | 60.00(0.024) | 36.00(0.014) | 6.270 | 0.012298 | 0.590 [0.389~0.896] |
| G | G | G | A | C | G | T | T | C | A | A | G | 12.00(0.005) | 12.00(0.005) | 0.000 | 0.987907 | 0.994 [0.446~2.216] |
| G | G | G | A | C | G | T | T | T | A | G | G | 1.00(0.000) | 0.00(0.000) | 1.006 | 0.315782 | — |
| A | A | A | A | C | G | T | T | C | A | A | G | 0.00(0.000) | 4.90(0.002) | 4.874 | 0.027288 | — |
| A | A | G | A | C | G | C | T | C | A | A | G | 0.00(0.000) | 0.80(0.000) | 0.799 | 0.371406 | — |
| A | A | G | G | A | G | C | C | C | A | G | A | 0.00(0.000) | 8.00(0.003) | 7.962 | 0.004789 | — |
| A | A | G | G | A | G | C | C | C | G | A | G | 0.00(0.000) | 0.50(0.000) | 0.496 | 0.481221 | — |
| A | A | G | G | A | G | C | C | C | G | G | A | 0.00(0.000) | 1.50(0.001) | 1.491 | 0.222007 | — |
| A | A | G | G | A | G | C | C | C | G | G | G | 0.00(0.000) | 1.50(0.001) | 1.491 | 0.222007 | — |
| A | A | G | G | A | G | C | T | C | A | A | G | 0.00(0.000) | 2.10(0.001) | 2.089 | 0.148303 | — |
| A | A | G | G | C | G | C | C | C | A | A | G | 0.00(0.000) | 1.01(0.000) | 1.008 | 0.315460 | — |
| A | A | G | G | C | G | C | T | C | A | A | G | 0.00(0.000) | 11.23(0.004) | 11.180 | 0.000831 | — |
| G | A | G | A | C | G | T | T | T | G | G | A | 0.00(0.000) | 12.00(0.005) | 11.952- | 0.000549 | — |
| G | G | A | A | C | A | T | T | T | G | A | G | 0.00(0.000) | 6.00(0.002) | 5.970 | 0.014571 | — |
| G | G | A | A | C | G | T | T | T | G | A | A | 0.00(0.000) | 12.00(0.005) | 11.952 | 0.000549 | — |
| G | G | A | G | C | G | C | T | T | A | A | G | 0.00(0.000) | 0.03(0.000) | 0.028 | 0.867129 | — |
A, AGBL4 rs320017 A > G; B, AGBL4 rs320018 A > G; C, AGBL4 rs320019 G > A; D, LRP8 rs6694764 G > A; E, LRP8 rs1288519 A > C; F, LRP8 rs872315 G > A; G, LRP8 rs1288520 C > T; H, LRP8 rs1288521 C > T; I, PCSK9 rs533375 C > T; J, PCSK9 rs584626 A > G;K, PCSK9 rs585131 A > G;L, PCSK9 rs540796 G > A; AGBL4, the ATP/GTP binding protein-like 4 gene; LRP8, the LDL receptor related protein 8 gene; PCSK9, the Proprotein convertase subtilisin/kexin type 9 gene.