Table 3.
Comparison of sugammadex and neostigmine on OR efficiency and clinical outcomes in an OR over 1 month in the reversal of moderate neuromuscular block
| Outcome Measure | Neostigmine | Sugammadex (2 mg/kg) | ||||||
|---|---|---|---|---|---|---|---|---|
| % of patients verified to have full neuromuscular recovery (TOF ratio ≥ 0.9) prior to extubation | ||||||||
| 0% | 5% | 10% | 25% | 50% | 75% | 100% | ||
| OR efficiency outcomes | ||||||||
| Number of OR minutes saved per day | – | 0 | 3 | 6 | 15 | 31 | 46 | 62 |
| % of days all procedures are completed within the regular OR day | 40.6% | 40.6% | 40.8% | 42.7% | 49.0% | 58.0% | 65.0% | 72.7% |
| Number of procedures performed | 90.8 | 90.8 | 90.9 | 91.0 | 91.6 | 92.5 | 92.9 | 93.0 |
| Procedures cancelled due to lack of OR time | 3.5 | 3.5 | 3.4 | 3.3 | 2.8 | 1.9 | 1.4 | 1.1 |
| Procedures cancelled for other reasons | 10.7 | 10.7 | 10.7 | 10.8 | 10.7 | 10.6 | 10.8 | 11.0 |
| Paid hours of staff over-time | 57.8 | 57.8 | 57.4 | 54.9 | 47.9 | 38.9 | 31.9 | 24.3 |
| Clinical outcomes | ||||||||
| Cases of residual blockade avoided | – | 51 | 48 | 46 | 38 | 25 | 13 | 0 |
| Hypoxemia cases avoideda | – | 12 | 12 | 11 | 9 | 6 | 3 | 0 |
| Upper airway obstruction cases avoideda | – | 23 | 21 | 20 | 17 | 11 | 6 | 0 |
| Absolute reduction in risk of residual blockade, per patient | – | 56% | 53% | 50% | 42% | 28% | 14% | 0% |
OR Operating room
aIncludes both cases which are and are not clinically diagnosed and managed