Table 4.
Sensitivity Analyses - For scenario where 100% of patients are verified to have full neuromuscular recovery (TOF ratio ≥ 0.9) prior to extubation in the OR
| Number of OR minutes saved per day | % of days all procedures are completed within the regular OR day | Procedures cancelled due to lack of OR time | Paid hours of staff over-time | |
|---|---|---|---|---|
| Primary Analysisa | ||||
| Neostigmine | – | 40.6% | 3.5 | 57.8 |
| Sugammadex | 62 | 72.7% | 1.1 | 24.3 |
| Cancel if < 50% of procedures can be completed within the regular OR day | ||||
| Neostigmine | – | 39.5% | 6.8 | 36.0 |
| Sugammadex | 62 | 73.7% | 1.9 | 16.5 |
| Never cancel a procedure due to lack of OR time | ||||
| Neostigmine | – | 40.4% | 0.0 | 92.0 |
| Sugammadex | 63 | 74.3% | 0.0 | 31.4 |
| Fully move up next procedure if a cancellation occurs | ||||
| Neostigmine | – | 63.2% | 2.4 | 32.3 |
| Sugammadex | 62 | 85.2% | 0.7 | 12.9 |
| Assume 15% of procedures are emergency cases | ||||
| Neostigmine | – | 19.8% | 16.1 | 108.5 |
| Sugammadex | 57 | 45.0% | 9.6 | 66.6 |
| Sugammadex OR time saved at lower bound of 95% CI in trials (2 min) | ||||
| Neostigmine | – | 40.6% | 3.5 | 57.8 |
| Sugammadex | 9 | 44.9% | 2.8 | 54.0 |
| Sugammadex OR time saved at lower bound of 95% CI in trials (26 min) | ||||
| Neostigmine | – | 40.6% | 3.5 | 57.8 |
| Sugammadex | 116 | 92.2% | 0.3 | 5.8 |
CI Confidence interval OR Operating room
aIn the primary analysis, procedures are cancelled if they cannot begin within the regular OR day, when a procedure is cancelled for any reason, the next procedure is not moved up, and no emergency cases occur