Table 1.
Baseline characteristics of total group and per treatment schedule
| PWS (n = 25) | Placebo/GH (n = 12) | GH / Placebo (n = 13) | p* | ||||
|---|---|---|---|---|---|---|---|
| Boys/girls (n) | 7/18 | 3/9 | 4/9 | ||||
| Genetic subtype | |||||||
| - Deletion | 9 | 2 | 7 | ||||
| - mUPD | 13 | 8 | 5 | ||||
| - ICD/translocation | 3 | 9 | 1 | ||||
| Age (yrs) | 17.8 | (15.7 to 18.5) | 17.2 | (14.9 to 19.4) | 17.8 | (16.9 to 18.0) | 0.852 |
| Adult height (SDS) | −1.7 | (−2.2 to–1.0) | −1.7 | (−2.4 to–1.1) | −1.8 | (−2.0 to −0.9) | 0.852 |
| BMI for age (SDS) | 1.1 | (−0.8 to 1.7) | 1.3 | (−0.4 to 1.7) | 1.1 | (−0.8 to 2.0) | 0.936 |
| BMI for age PWS (SDS) | −1.1 | (−2.2 to −0.6) | −1.2 | (−2.2 to −0.6) | −1.1 | (−2.3 to −0.5) | 0.689 |
| Age at start GH treatment (yrs) | 8.8 | (6.3 to 10.1) | 8.1 | (5.8 to 9.8) | 8.8 | (6.9 to 11.2) | 0.376 |
| Duration of GH treatment (yrs) | 8.6 | (7.0 to 10.5) | 8.7 | (7.2 to 11.4) | 8.3 | (6.5 to 10.5) | 0.650 |
| IGF-I (SDS) | 2.1 | (1.7 to 3.0) | 1.7 | (1.1 to 3.0) | 2.2 | (2.0 to 3.0) | 0.051 |
| FM% | 38.6 | (32.3 to 44.9) | 39.0 | (32.4 to 45.6) | 37.3 | (30.5 to 44.9) | 0.810 |
| Lean body mass (kg) | 36.5 | (30.6 to 41.5) | 35.0 | (29.6 to 43.9) | 37.0 | (33.2 to 40.2) | 0.611 |
| Total IQ | 62 | (56 to 73) | 60 | (54 to 63) | 67 | (57 to 78) | 0.095 |
| Verbal IQ | 65 | (57 to 72) | 66 | (60 to 72) | 65 | (55 to 74) | 0.713 |
| - Vocabulary | −2.3 | (−2.8 to −1.7) | −2.3 | (−2.8 to −1.8) | −2.0 | (−2.8 to −1.4) | 0.464 |
| - Similarities | −2.0 | (−2.5 to −1.0) | −2.0 | (−2.7 to −1.5) | −1.7 | (−2.5 to −0.8) | 0.382 |
| - Arithmetic | −2.0 | (−2.0 to −1.7) | −2.0 | (−2.3 to −1.6) | −2.0 | (−2.0 to −1.6) | 0.635 |
| - Digit Span | −2.0 | (−2.3 to −2.0) | −2.0 | (−2.0 to −1.2) | −2.3 | (−2.4 to −1.9) | 0.129 |
| - Information | −1.7 | (−2.0 to −1.3) | −1.7 | (−1.8 to −1.3) | −1.8 | (−2.0 to −1.3) | 0.792 |
| - Comprehension | −2.0 | (−2.6 to −1.5) | −2.2 | (−2.7 to −1.6) | −2.0 | (−2.4 to −1.2) | 0.792 |
| Performance IQ | 60 | (54 to 72) | 59 | (54 to 67) | 66 | (52 to 74) | 0.635 |
| - Picture Completion | −2.5 | (−3.0 to −1.5) | −2.5 | (−2.8 to −1.7) | −2.5 | (−3.0 to −1.3) | 0.792 |
| - Coding | −3.0 | (−3.0 to −2.3) | −3.0 | (−3.0 to −2.6) | −2.9 | (−3.0 to −1.6) | 0.428 |
| - Block design | −2.2 | (−2.2 to −1.3) | −2.0 | (−3.0 to −1.5) | −1.5 | (−1.9 to −0.8) | 0.034 |
| - Matrix Reasoning | −2.3 | (−2.3 to −1.3) | −2.0 | (−2.3 to −1.7) | −2.0 | (−2.3 to −1.0) | 0.786 |
| - Picture Arrangement | −2.7 | (−2.7 to −1.5) | −2.3 | (−2.8 to −1.8) | −1.7 | (−2.0 to −1.4) | 0.082 |
Data expressed as median (IQR). *Comparison between two treatment schedules