Fig. 3.

a Putative target list enrichment for individual miRs using TargetScan and DIANA-microT target lists (first and second row, respectively). Relative enrichment of combined miR target lists are also shown for GO terms associated with pigmentation or EMP. b Relationships between miR-29b-3p and LAMC1 (left), LASP1 (centre) and PPIC (right) within the LM-MEL data; for cell lines with matrigel invasiveness measurements, these data are overlaid (red, high invasiveness; blue, low invasiveness). c miR transcript abundances measured by quantitative PCR (qPCR; bar graph) for selected miRs and LM-MEL cell lines (indicated by number along the x-axis), plotted against high-throughput LM-MEL panel data (black triangles); adjusted regression coefficients between these datasets are indicated (negative for miR-211-5p due to multiple non-expressing cell lines)