Table 1.
Demography, lifetime and current history of psychiatric disorders
| 22q11.2DS (n = 29) | Controls (n = 29) | |||
|---|---|---|---|---|
| Mean age (SD) | 15.7 (2.8) | 16.0 (2.8) | ||
| Male/female ratio | 19:10 | 19:10 | ||
| Caucasian ancestry | 29 | 29 | ||
| 3 megabase deletion | 29 | 0 | ||
| Intelligence quotient (range)a | 79.52 (35–113) | 108.76 (87–129) | ||
| Psychiatric diagnoses % | Lifetimeb | Currenta–e | Lifetimeb | Currenta–e |
| Schizophrenia spectrum disorders (F2x)c | 0 | 0 | 0 | 0 |
| Affective disorders (F30-F33)d | 3.4 | 3.4 | 0 | 0 |
| Anxiety and phobia (F4x)d | 3.4 | 34.5 | 0 | 13.8 |
| Intellectual disability (F7x)a | 17.2 | 20.1 | 0 | 0 |
| Autism spectrum disorders (F84.x)e | 13.8 | 13.8 | 0 | 0 |
| Disturbance of activity and attention/attention-deficit disorder without hyperactivity (F90.0/98.8C)d | 3.4 | 3.4 | 0 | 0 |
aIntelligence quotient score was derived from the Reynolds Intellectual Screening Test (RIST) [48]. Indication of current intellectual disability was indexed by RIST IQ below 70
bLifetime diagnoses according to International Classification of Diseases (ICD-10) obtained from the Danish Psychiatric Central Register [51]
cCurrent diagnosis of schizophrenia was obtained from the Structured Interview for Prodromal Syndromes
dCurrent diagnoses of affective disorder, anxiety, and disturbance of activity and attention/attention-deficit disorder without hyperactivity were provided by use of the Mini International Neuropsychiatric Interview [45, 82] or the Mini International Neuropsychiatric Interview for Children and Adolescents [46]
eIndications of current autism spectrum disorders (ASD) was determined from parental reporting using the Social Communication Questionnaire lifetime form. Clinical cut-off of 15 indicates ASD [49, 50]