Table 2.
Associations of birth weight-for-gestational age (BW/GA) with DNA methylation sitesa in venous umbilical cord blood at delivery, among 476 participants in Project Viva
| CpG sitea | Difference in % methylation for 1-unit increment in BW/GA z-score (95% CI) | Nominal p value | Geneb | Gene regionb | chr |
|---|---|---|---|---|---|
| cg26663636 | −0.39 (−0.52, −0.25) | 4.31E−09 | NOS1AP | Body | chr1 |
| cg18181229 | 1.86 (1.16, 2.56) | 1.80E−07 | PBX1 | Body | chr1 |
| cg06750897 | 1.93 (1.22, 2.64) | 1.83E−07 | PBX1 | Body | chr1 |
| cg00222472 | 1.78 (1.12, 2.45) | 2.03E−07 | PBX1 | Body | chr1 |
| cg20682146 | 1.54 (0.91, 2.17) | 1.60E−06 | PBX1 | Body | chr1 |
| cg05780177 | 0.24 (0.14, 0.35) | 2.39E−06 | DENND1B | TSS200 | chr1 |
| cg00325458 | 0.1 (0.06, 0.14) | 7.27E−07 | REL | TSS200 | chr2 |
| cg23483765 | 0.22 (0.14, 0.31) | 1.15E−07 | NIPAL4 | TSS200 | chr5 |
| cg24353833 | 0.42 (0.27, 0.57) | 8.38E−08 | NRM | Body | chr6 |
| cg24641186 | 0.46 (0.27, 0.64) | 1.41E−06 | TFAP2B | Body | chr6 |
| cg20392842 | −1.58 (−2.24, −0.92) | 2.54E−06 | HLA-DMB | TSS200 | chr6 |
| cg09364590 | 0.72 (0.42, 1.03) | 3.66E−06 | TIAM2 | Body;TSS200 | chr6 |
| cg21809331 | 0.22 (0.13, 0.31) | 2.28E−06 | RBM28 | TSS200 | chr7 |
| cg14731462 | −0.92 (−1.29, −0.55) | 4.20E−07 | PTPRE | 5′UTR | chr10 |
| cg25953130 | −2.01 (−2.8, −1.22) | 7.76E−07 | ARID5B | Body | chr10 |
| cg23890469 | 0.57 (0.34, 0.81) | 1.55E−06 | MMRN2 | Body | chr10 |
| cg25124943 | −0.92 (−1.31, −0.53) | 2.34E−06 | – | – | chr10 |
| cg11606444 | 0.68 (0.39, 0.98) | 4.28E−06 | SORL1 | Body | chr11 |
| cg01345517 | 0.15 (0.09, 0.21) | 1.55E−06 | DERA | Body | chr12 |
| cg06648759 | −1.08 (−1.52, −0.63) | 2.02E−06 | – | – | chr13 |
| cg14276580 | −0.94 (−1.33, −0.54) | 2.24E−06 | – | – | chr13 |
| cg20549688 | 0.21 (0.13, 0.29) | 3.20E−07 | GTF2A2 | TSS200 | chr15 |
| cg21842999 | 0.51 (0.3, 0.72) | 3.20E−06 | SHF | Body | chr15 |
| cg09476997 | 1.81 (1.06, 2.57) | 2.20E−06 | SLC9A3R2 | Body; | chr16 |
| cg27283514 | 1.51 (0.86, 2.16) | 3.34E−06 | – | – | chr16 |
| cg19914554 | 0.73 (0.47, 0.98) | 2.21E−08 | CD7 | 1stExon;5′UTR | chr17 |
| cg20186396 | 0.73 (0.45, 1.02) | 3.26E−07 | CD7 | TSS200 | chr17 |
| cg14909906 | 0.17 (0.1, 0.25) | 2.37E−06 | KDSR | 1stExon;5′UTR | chr18 |
| cg23882285 | 0.12 (0.07, 0.17) | 3.37E−06 | ROCK1 | TSS200 | chr18 |
| cg23026246 | 0.13 (0.08, 0.19) | 2.23E−06 | SPTBN4 | Body | chr19 |
| cg23877608 | 0.17 (0.1, 0.24) | 2.35E−06 | CCDC114 | TSS200 | chr19 |
| cg23344780 | −0.58 (−0.83, −0.33) | 4.10E−06 | EMP3 | 5′UTR | chr19 |
| cg04803921 | 0.13 (0.08, 0.19) | 1.68E−06 | HM13 | Body | chr20 |
| cg08422803 | 1.05 (0.69, 1.41) | 8.04E−09 | ITGB2 | TSS200;5′UTR | chr21 |
Chr chromosome, UTR untranslated region, TSS transcription start site
aCpGs are ordered according to chromosome number
bGene and gene region information are according to annotation information from Illumina. Dashed lines indicate that the CpG is annotated to an intergenic region