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. 2016 Nov 16;17:923. doi: 10.1186/s12864-016-3228-7

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Cluster analysis of the salivary gland developmental profile. a Z-scores for each of the 1924 genes were calculated and used as input for gene-wise K-Means clustering analysis (k = 8, 1000 repetitions). This analysis, visualized as a heatmap, depicts enrichment of genes at both specific development time points and general developmental stages (embryo, neonatal and adult). b Visualization of the gene Z-scores from the general developmental stage enriched clusters depicts unique time-dependent patterns of expression. In general, this analysis has identified genes that have peak expression in the defined developmental stages. Also show are selected enriched GO-Annotations for each developmental stage gene cluster (BiNGO, Hypergeometric Test, FDR < 0.1)