. Author manuscript; available in PMC: 2016 Nov 17.

Published in final edited form as: ACS Chem Neurosci. 2015 Apr 15;6(5):751–760. doi: 10.1021/acschemneuro.5b00013

Table 1.

Statistical analysis of the effects of compounds aza-8, aza-9, aza-12, and aza-13 on the stabilization of microtubules.

		t_i (min)			k_app (min⁻¹)			Max (A₃₄₀)

Aza-8	−	3.08	±	1.28	0.87	±	0.14	0.76	±	0.36
Aza-8	+	13.42	±	6.59	0.12	±	0.02***	0.36	±	0.14*
Aza-9	−	2.26	±	0.65	0.62	±	0.08	0.65	±	0.38
Aza-9	+	5.03	±	1.93	0.26	±	0.19*	0.38	±	0.10*
Aza-12	−	3.11	±	1.22	0.78	±	0.09	0.75	±	0.10
Aza-12	+	12.83	±	1.35***	0.09	±	0.02***	0.50	±	0.04*
Aza-13	−	2.58	±	1.29	0.86	±	0.17	0.72	±	0.06
Aza-13	+	15.65	±	7.72*	0.12	±	0.05**	0.30	±	0.07**

Max (A₃₄₀) is the maximum amount of microtubule polymerization, t_i is the point of inflection of the curve at the time of maximum growth rate in minutes, and b is inversely proportional to the apparent rate of polymerization (k_app, min⁻¹) as determined from the fit of three individual microtubule polymerization curves for each condition to a nonlinear Gompertz growth function (see Methods).