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. 2016 Nov 16;11(11):e0166450. doi: 10.1371/journal.pone.0166450

Fig 2. DRB modulates the phosphorylation and subcellular localization of αB-crystallin.

Fig 2

(A) DRB treatment alone for various durations reduced αB-crystallin protein expression and P-αB-crystallin-Ser-19, Ser-45 and Ser-59 levels in a time-dependent manner. (B) DRB treatment induced the partial loss of cytoplasmic and nuclear αB-crystallin, whereas P-αB-crystallin-Ser19 and P-αB-crystallin-Ser45 localization within SC35 speckles was sustained. Each experiment, six in total, was conducted with three animals each. In each experiment, the cells from three animals were pooled and analyzed in triplicate.