Table 2. Associations between body fat% GRS and CRF expressed in VO2max (ml/kg/min), VO2maxFFM (ml/kg FFM/min) as well as VO2maxFM (ml/kg FM/min) after meta-analysis of two Danish cohorts (ADDITION-PRO (n = 716) and Health2006 (n = 2490)).
| Trait | Covariates | Per allele effect size on CRF (95% CI) | P |
|---|---|---|---|
| VO2max (ml/kg/min) | age, sex | -0.15 (-0.26 to -0.05) | 0.0034 |
| VO2max (ml/kg/min) | age, sex, body fat% | -0.05 (-0.15 to 0.04) | 0.27 |
| VO2max (ml/kg/min) | age, sex, fat-free mass | -0.11 (-0.21 to -0.0006) | 0.04 |
| VO2maxFFM (ml/kg FFM/ min) | age, sex | -0.06 (-0.19 to 0.07) | 0.38 |
| VO2maxFFM (ml/kg FFM/min) | age, sex, body fat% | -0.07 (-0.20 to 0.06) | 0.30 |
| VO2maxFM (ml/kg FM/ min) | age, sex | -0.01 (-0.02 to -0.007) | < 0.0001 |
| VO2maxFM (ml/kg FM/min) | age, sex, fat-free mass | -0.008 (-0.01 to -0.003) | 0.0033 |
Associations between body fat% GRS and CRF were examined by linear regression using additive genetic models. Data for VO2maxFM was log-transformed. Models were adjusted for age and sex or age, sex and body composition. Cohort specific association results can be found in S3 Table.