Table 3. Associations between the FTO rs1558902 A-allele and VO2max (ml/kg/min), VO2maxFM (ml/kg FFM/min) as well as VO2maxFFM (ml/kg FM/min) after meta-analysis of two Danish cohorts (ADDITION-PRO (n = 716) and Health2006 (n = 2586)), assuming a fixed effect model.
| Covariates | Effect | SE (range) | P | |
|---|---|---|---|---|
| VO2max (ml/kg/min) | mage, sex | -0.42 | (-0.74 to -0.09) | 0.0092 |
| VO2max (ml/kg/min) | age, sex, BMI | -0.11 | (-0.40 to 0.18) | 0.46 |
| VO2max (ml/kg/min) | age, sex, fat-free mass | -0.22 | (-0.54 to 0.09) | 0.17 |
| VO2maxFFM (ml/kg FFM/min) | age, sex | -0.12 | (-0.53 to 0.30) | 0.58 |
| VO2maxFFM (ml/kg FFM/min) | age, sex, BMI | -0.07 | (-0.47 to 0.34) | 0.74 |
| VO2maxFFM (ml/kg FFM/min) | age, sex, fat- mass | -0.004 | (-0.02 to 0.16) | 0.68 |
| VO2maxFM (ml/kg FM/min) | age, sex | -0.03 | (-0.05 to -0.01) | 0.00040 |
| VO2maxFM (ml/kg FM/min) | age, sex, BMI | -0.0019 | (-0.01 to 0.010) | 0.76 |
| VO2maxFM (ml/kg FM/min) | age, sex, fat-free mass | -0.01 | (-0.03 to 0.002) | 0.080 |
Associations between of the A- allele of FTO rs1558902 and CRF, expressed in VO2max (ml/kg/min), VO2maxFFM (ml/kg FFM/min) as well as VO2maxFM (ml/kg FM/min), were examined by linear regression assuming additive genetic models. Data for VO2maxFM was log-transformed. Models were adjusted for age and sex or age, sex and body composition. Study characteristics of ADDITION-PRO (n = 716) and Health2006 (n = 2586) according to FTO rs1558902 genotype can be found in S6 Table. Cohort specific association results can be found in S4 Table.