Table 1. Excipient Content in Formulations Prepared for Liquid Stability Screening.
Formulation | Sucrose | Trehalose | Mannitol | Glycine | Dextran 40 | Arginine | NaH2PO4 | NaCl |
---|---|---|---|---|---|---|---|---|
Final Concentration (% w/w) | mM | |||||||
F1 | 5 | 20 | 14 | |||||
F2 | 5 | 20 | 14 | |||||
F3 | 5 | 20 | 14 | |||||
F4 | 5 | 20 | 14 | |||||
F5 | 5 | 20 | 14 | |||||
F6 | 5 | 20 | 14 | |||||
F7 | 20 | 14 | ||||||
F8 | 20 | 140 |
All formulations contained 0.09% polysorbate 80, which was already present in the bulk vaccine.