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. 2016 Nov 16;11(11):e0166454. doi: 10.1371/journal.pone.0166454

Fig 1. Histopathological evaluation of SC-injected ANE-induced changes in dermal thickness.

Fig 1

(A.) The skin injection sites were examined by H&E staining on days 3, 7, 14, and 30. The sections were viewed under a microscope at 100x magnification. Scale bars indicate 100 μm. (B). Quantification of the average dermal thickness of the tissue using IMAGE-Pro software. Each treatment group included at least 6 mice. The results are shown as the mean± SD. The levels of statistical significance are as follows: *P<0.05, **P<0.01 and ***P<0.001 relative to the control group.