Table 4. Diseases and functions activated in E. faecalis-colonised CRCs (p≤0.05, |z-score| ≥ 2).

Boldface entries were also significant in the comparison between B vs. A group CRCs.

Categories	Diseases or Functions Annotation	p-Value	Activation z-score
Cellular Growth and Proliferation	proliferation of cells	1.70E-04	3.9
Cellular Development, Skeletal and Muscular System Development and Function, Tissue Development	differentiation of smooth muscle cells	3.90E-04	2.2
Cancer	metastasis	9.50E-04	3.1
Cellular Movement	invasion of tumour cell lines	9.70E-04	2.9
Connective Tissue Disorders, Developmental Disorder, Skeletal and Muscular Disorders	craniofacial abnormality	2.80E-03	-2.4
Cellular Movement	invasion of cells	6.90E-03	2.8
Cellular Development	epithelial-mesenchymal transition	7.00E-03	2.6
Cellular Movement	invasion of breast cancer cell lines	7.40E-03	2.1
Cardiovascular System Development and Function	neovascularization	8.60E-03	2
Cancer	neoplasia of cells	1.10E-02	2.2
Organismal Development	size of body	1.30E-02	3.9
Inflammatory Disease, Respiratory Disease	pulmonary emphysema	1.50E-02	-2.2
Cellular Development	epithelial-mesenchymal transition of tumour cell lines	1.50E-02	2.3
Developmental Disorder, Immunological Disease	hypoplasia of thymus gland	1.80E-02	-2.6
Cellular Movement	cell movement of colon cancer cell lines	1.80E-02	2.6
Cellular Movement	migration of colon cancer cell lines	1.90E-02	2.4
Cellular Development, Skeletal and Muscular System Development and Function, Tissue Development	differentiation of muscle cells	2.10E-02	2.2
Cell-To-Cell Signaling and Interaction, Tissue Development	adhesion of epithelial cells	2.30E-02	2