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. 2016 Nov 15;11(11):e0166378. doi: 10.1371/journal.pone.0166378

Table 2. Effect of berberine treatment on glucose tolerance test in ZDF rats.

0 weeks	Groups	Time/min				AUC/mmol ⋅L⁻¹⋅h⁻¹
	Groups	0	30	60	120	AUC/mmol ⋅L⁻¹⋅h⁻¹
	Con	5.97±0.48	7.90±0.32	7.52±0.41	5.67±0.35	13.91±0.47
	DM	17.25±4.06^▲▲	28.42±2.83^▲▲	29.60±2.04^▲▲	25.83±3.29^▲▲	53.64±5.19^▲▲
	BBR	14.23±5.51	24.67±5.27	28.22±6.77	22.80±6.72	48.46±12.21
12^th week	Groups	Time/min				AUC/mmol ⋅L⁻¹⋅h⁻¹
	Groups	0	30	60	120	AUC/mmol ⋅L⁻¹⋅h⁻¹
	Con	5.90±0.73	6.83±1.04	5.57±1.17	4.80±0.90	11.47±1.58
	DM	27.68±1.18^▲▲	33.40±0.00^▲▲	33.35±0.12^▲▲	29.27±0.64^▲▲	63.27±0.52^▲▲
	BBR	25.08±1.07^★★	33.37±0.08	32.92±1.14	28.67±0.88	61.98±1.02^★

AUC, area under curve. Data presented as the mean values ± standard deviation (SD).

^▲▲P<0.01 compared to normal control (Con)

^★★P<0.01

^★P<0.05 compared to diabetic control (DM).