Table 1. Mutational status of human lung cancer cell lines.

	Cell line	Histology	EGFR	KRAS	ALK	BRAF	MET	RET	ROS1	ERBB2	PTEN
PD-L1 high	NCI-H1373	Ad	wt	G12C	p.E1435dela	wt	wt	wt	wt	wt	wt
	NCI-H441	Ad	wt	G12V	wt	wt	wt	wt	wt	wt	wt
	NCI-H647	Ad	wt	G13D	wt	wt	wt	wt	wt	wt	wt
	NCI-H1650	Ad	p.ELREA746del	wt	wt	wt	wt	wt	wt	wt	wt
	NCI-H358	Ad	wt	G12C	wt	wt	wt	wt	wt	wt	wt
	NCI-H1975	Ad	L858R, T790M	wt	wt	wt	wt	wt	wt	wt	wt
	NCI-H226	Sq	wt	wt	wt	wt	wt	wt	wt	wt	wt
	SK-MES-1	Sq	wt	wt	wt	wt	wt	wt	wt	wt	wt
	EBC-1	Sq	wt	wt	wt	wt	wt	wt	wt	wt	wt
	NCI-H460	La	wt	Q61Hb	wt	wt	wt	wt	wt	wt	wt
PD-L1 low	SK-LU-1	Ad	wt	G12D	wt	wt	wt	wt	wt	wt	wt
	VMRC-LCD	Ad	wt	wt	wt	wt	wt	wt	wt	wt	wt
	ABC-1	Ad	wt	wt	wt	wt	wt	wt	wt	wt	wt
	RERF-LC-MS	Ad	wt	wt	wt	wt	wt	wt	wt	wt	wt
	NCI-H23	Ad	wt	G12C	wt	wt	wt	R77Lc	wt	wt	wt
	NCI-H522	Ad	wt	wt	wt	wt	wt	wt	wt	wt	wt
	NCI-H2170	Sq	wt	wt	wt	wt	wt	wt	wt	wt	wt
	LK-2	Sq	wt	wt	wt	wt	wt	wt	wt	wt	wt
	SBC-5	SCLC	wt	wt	wt	wt	wt	wt	wt	S1050Le	wt
	DMS114	SCLC	wt	wt	wt	wt	wt	wt	T870Nd	wt	wt

wt: wild type

^a, E1435 resides downstream of the tyrosine kinase domain (1116–1383) of ALK; its significance is unknown.

^b, Q61H is a minor mutation in exon 3 of KRAS.

^c, R77L of RET is located at the N-terminus; its significance is unknown.

^d, T870N of ROS1 resides outside any known motifs; its significance is unknown.

^e, S1050L of ERBB2 resides near the Tyr1054 residue downstream of the tyrosine kinase domain; its significance is unknown.