Figure 4. αCT1 sensitizes GBM cells to TMZ.
(A) αCT1 peptide is composed of an antennapedia cell internalization domain and 9 amino acids at the CT of Cx43 (i.e., rprpddlei). Viability of SF295 (B), U87MG, (C), VTC-003 (D), LN229 (E), U251 (F), VTC-037 (G), and VTC-005 (H) cells treated with αCT1 and/or TMZ for 1–2 weeks. Error bar depicts standard deviation from experiments performed in triplicate. * p<0.05.