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. 2016 Nov 16;11(11):e0166178. doi: 10.1371/journal.pone.0166178

Fig 7. Hepatobiliary bile acid profiles.

Fig 7

A. Total bile acids. Total bile acids and total conjugated bile acids were lower (but did not reach significance) in livers of mice from the HFWD-Ca group. B. Muricholic acid (MCA) and derivatives. TbMCA was significantly reduced in livers of HFWD-Ca mice (asterisk, p<0.00001, unpaired t test, Holm-Sidak correction for multiple comparisons). C. Low-prevalence MCA derivatives were also lower in the HFWD-Ca group, although this did not reach significance. D. Cholic acid (CA), chenodeoxycholic acid (CDCA) and derivatives. No differences between groups were seen (note y axis values indicating lower overall prevalence of CA/CDCA derivatives in mice in comparison to MCA). E. Low-prevalence CA derivatives. No differences between groups were seen. Data shown for all panels is from randomly selected mice without tumors (n = 7 for HFWD, n = 5 for HFWD-Ca).