Fig 2. Effect of local umwelt on EC patterning speeds.

(A) Illustration of simulation where the 2-cell model is initialized as 2 quiescent ECs (Q1 and Q2) in an environment of VEGF gradient and we ask how long does it take the 2-cell model to pattern into A:I (Active cell1:Inactive cell2) or I:A (Inactive cell1:Actitve cell2). (B) Matrix plot of the 2-cell system patterning speeds under different combinations of V₁ and V₂. (C) Illustration of simulation where 2-quiescent cells (Q1 and Q2) bounded by neighbors with high DLL (D_ext1) and low internal DLL (D_ext2) respectively. (B) Matrix plotting the patterning speeds under different combinations of V_1/2 and constant D_ext. (C) Illustration of simulation where 2-quiescent cells (Q1 and Q2) bounded by neighbors that can have different DLL_ext1/ext2 values at start of each simulation. (B) Matrix plotting the patterning speeds under different combinations of D_ext1/ext2. In all conditions Active cells with high DLL are white, inactive cells with high notch are purple. Patterning time is indicated as a color scale where red indicates slow patterning speeds and color ranges of blue to white indicate faster patterning speeds.