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. 2016 Sep 21;5(9):e104. doi: 10.1038/emi.2016.101

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Copyright © 2016 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Maximum likelihood phylogenetic tree of 269 EV-A71 VP1 sequences. The branches are color-coded according to the location of sample collection (Cambodia=red, Vietnam=blue, Thailand=purple and China=green). For better clarity, taxon names are not shown, and sequences from other locations beside the four countries are not color-coded. The sequences isolated from Cambodian patients with different disease categories of severity are marked by white triangles for hand, foot and mouth disease, white rectangles for central nervous system involvement and black circles for cardiopulmonary failure. The tree was built using the maximum likelihood method based on the GTR+G4 model. The robustness of nodes was assessed with 1000 bootstrap replicates. Bootstrap values <70 are not shown.