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. 2016 Aug 9;24(9):1627–1633. doi: 10.1038/mt.2016.139

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Copyright © 2016 Official journal of the American Society of Gene & Cell Therapy

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Retardation of SKOV-3 or HepG2 tumor growth in mice dosed IV with 1 × 10⁶ copies of vaccinia virus (VV). A dose of 1 × 10⁶ luciferase expressing VV was injected IV with cups with or without the application of ultrasound (US) (see Methods). Tumor size was assessed by caliper measurements. Growth profile shown for each individual tumor. n = 4. Panels a and b present SKOV-3 tumors, c and d present HepG2. Panels b and d are mice treated with cups + VV + US.