Table 3.

Univariable and Multivariable Cox Regression for allograft loss.

	Univariable			Multivariable
variable	HR	p value	95% CI	HR*	p value	95% CI
Viral Factors
HIV−/HCV−	REF			REF
HCV+	1.66	<0.001	1.58–1.74	1.43	<0.001	1.31–1.56
HIV+	1.42	<0.001	1.18–1.71	0.60	0.01	0.40–0.88
HIV+/HCV+	3.18	<0.001	2.48–4.08	2.59	<0.001	1.60–4.19
Recipient Age
Age <40 years	REF			REF
Age 40–60 years	1.01	0.53	0.98–1.04	0.82	<0.001	0.78–0.88
Age >60 years	1.58	<0.001	1.53–1.63	1.09	0.002	1.03–1.16
Other recipient factors
Male	0.91	<0.001	0.89–0.93	0.94	0.006	0.91–0.98
African American	1.50	<0.001	1.47–1.54	1.27	<0.001	1.22–1.32
Pre-transplant diabetes	1.50	<0.001	1.46–1.53	1.34	<0.001	1.28–1.39
PRA ≥30%	1.14	<0.001	1.10–1.18	0.99	0.78	0.94–1.05
Pre-transplant dialysis	1.14	<0.001	1.13–1.16	1.60	<0.001	1.48–1.72
Transplant Factors
Deceased donor	1.74	<0.001	1.70–1.79	1.42	<0.001	1.34–1.50
Expanded criteria donor	2.05	<0.001	1.99–2.11	1.41	<0.001	1.34–1.48
CDC high risk donor	0.96	<0.001	0.96–0.96	-	-	-
Diabetic donor	1.81	<0.001	1.72–1.90	1.19	<0.001	1.10–1.28
HCV+ donor	2.11	<0.001	1.97–2.27	1.70	0.001	1.25–2.32
HCV donor* HCV recipient	0.66	<0.001	0.55–0.80	0.64	0.01	0.46–0.91
Acute rejection in 1st year	1.81	<0.001	1.75–1.88	1.86	<0.001	1.77–1.95
Antibody induction use
Lymphodepleting	REF			REF
Non-lymphodepleting	1.06	<0.001	1.03–1.09	1.16	<0.001	1.11–1.21

^*HR is adjusted to reflect tacrolimus based immunosuppression and an interaction term for transplant year and tacrolimus use.