Table - PMC

. Author manuscript; available in PMC: 2016 Dec 1.

Published in final edited form as: Curr Opin Infect Dis. 2016 Dec;29(6):561–576. doi: 10.1097/QCO.0000000000000323

Antimicrobial allergy “label”	Antimicrobials to avoid in the setting of known T-cell-mediated ADR history
Penicillin V/G	Cephalothin Cefoxitin
Aminopenicillins	Ampicillin/amoxicillin Cefaclor^a Cephalexin^a
Anti-staphylococcal penicillin	Penicillin V/G Flucloxacillin/dicloxacillin/oxacillin Piperacillin-tazobactam Ticarcillin-clavulanate
1^st Generation cephalosporins^b	Amoxicillin^c Cefaclor^d
2^nd Generation cephalosporins	Ceftriaxone^e Cefotaxime^e Cefepime^e Cephalexin^f
3^rd Generation cephalosporins	Cefepime^g Cephalothin^h Cefuroxime^g Cefotaxime^g
4^th Generation cephalosporins	Aztreonamⁱ Cefitraxone^j Cefuroxime^j Cefotaxime^j
Carbapenems	Carbapenems
Monobactams	Ceftazadime^k
Antibiotic sulphonamides	Nil

References:[79,152,167–174]

Abbreviations:

SCAR, severe cutaneous adverse reactions: Stevens-Johnson syndrome, toxic epidermal necrolysis; drug reaction with eosinophilia and systemic symptoms; acute generalised exanthematous pustolosis.

ADR, adverse drug reaction.

Avoid if amoxicillin/ampicillin delayed IM-ADR due to shared/similar R1 side chain

If cefazolin is the implicated antimicrobial, this is generally an isolated reaction due to the absence of shared side chains and therefore other beta-lactams could be employed for non-SCAR phenotypes.

If cephalexin allergy then avoid amoxicillin/ampicillin due to shared/similar R1 side chain

Avoid if cephalexin allergy due to shared/similar R1 side chain

Avoid if cefuroxime allergy due to shared/similar R1 side chain

Avoid if cefaclor allergy, due to shared/similar R1 side chain

Avoid if ceftriaxone allergy due to shared/similar R1 side chain.

Avoid if cefoxitin allergy due to shared/similar R1 side chain.

ⁱ

Avoid if ceftazadime allergy due to shared/similar R1 side chain

Avoid if cefepime allergy due to shared/similar R1 side chain

Avoid if aztreonam allergy due to shared/similar R1 side chain