Table 1.

Model Parameters: Eq. 5

Parameter	Definition	Range	Value Used	Source
ρ	line density of material at the ring channel opening	1–2 pg/μm3	1–2 pg/μm3	(45)
r0	initial ring channel radius	1–2 μm	1 μm	this study
η	viscous resistance of actin meshwork	1–100 kPa·s = 1–100 × 1012 pg/μm·s	1 × 1012 pg/μm·s	(46, 47)
kc	force generator spring constant	1–100 × 109 pg/s2 = 1–100 pN/μm	5 × 109 pg/s2	(48, 49, 50, 51)
mc	line density of tangential force generators	200–300/μm	250/μm	(30, 42, 43)
fn	force generated per molecule	1–10 × 109 pg·μm/s2 = 1–10 pN	5 × 109 pg·μm/s2	(49, 52, 53)
mn	line density of normal force generators	200–300/μm	250/μm	(30, 42, 43)
ai, i = n, c	time of half max of protein reduction due to RNAi	30,000–50,000 s	40,000 s	(57), this study