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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Alcohol Clin Exp Res. 2016 Sep 26;40(11):2359–2367. doi: 10.1111/acer.13223

Figure 6.

Figure 6

Intra-IC injection of PKA signaling inhibitors decreases the prevalence of acoustically evoked AWSs. The percentage of post-drug was corrected to the percentage of vehicle (control, CON). A. KT-5720 (or CON) was microinjected bilaterally into the IC (2.5 μg/hemisphere) of rats following ethanol withdrawal. Two hours after microinjection, the prevalence of WRSs and clonus seizures was measured. B. Rp-cAMPS (or CON) was microinjected bilaterally into the IC (5 μg/hemisphere) of rats following ethanol withdrawal. Two hours after microinjection, the incidence of wild running seizures (WRS) and clonus seizures was measured. ****P<0.0001 (χ2 test; n=6 per group).