Figure 3. WRCs are essential for normal bone callus architecture and fracture stabilization after injury.

(A-B’), μCT three-dimensional isosurface (A,B) and serial sections (A’,B’) from representative PBS-treated (A-A’) and DT-treated (B-B’) tibiae in Axin2^CreER;R26^mTmG;R26^{tm1(HBEGF)Awai}transgenic mice delineate the woven bony regenerate (red, A-B’) versus the surrounding cortical bone (green, A-B’). Three-dimensional isosurface rendering and serial sections with finite element modeling of first principle (tensile) strain fields in representative PBS-treated (C-C’) and DT-treated (D-D’) tibiae in Axin2^CreER;R26^mTmG;R26^{tm1(HBEGF)Awai}transgenic mice. The rainbow legend indicates tensile strain values within both isosurface and serial renderings. Scale bars are equal to 100 μm.