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Visualizations of the activity of the ribozyme mutants. A) Relative activity (RA) of 144 single mutants of the Osa‐1‐4 ribozyme. B) Two‐dimensional RA matrix of all single and double mutants of the Osa‐1‐4 ribozyme. Single mutants are represented on the diagonal side. Several characteristic clusters of double mutants are shown in the boxes and are discussed in the main text. The full RA matrix with numerical RA data and mutations is provided in the Supporting Information.
