Table 5.
Symptoms and quality of life by age group in men randomized in the ProtecT trial
| Age group | 49–54 years | 55–59 years | 60–64 years | 65–70 years | P * |
|---|---|---|---|---|---|
| Symptoms (MID)† | |||||
| Minimum analysed/asked, n/N (%) | 76/87 (87) | 200/225 (89) | 220/270 (81) | 223/267 (84) | |
| Urinary summary (4.6) | 93.1 (9.9) | 94.0 (7.2) | 92.2 (9.5) | 92.0 (9.9) | 0.022 |
| Urinary function (4.2) | 92.9 (12.8) | 95.7 (7.0) | 94.9 (8.0) | 95.3 (8.1) | 0.627 |
| Urinary bother (5.9) | 93.3 (10.3) | 92.7 (9.2) | 90.2 (12.4) | 89.6 (13.1) | <0.001 |
| Bowel summary (4.2) | 93.7 (10.3) | 93.1 (8.6) | 93.1 (8.2) | 94.4 (7.6) | 0.357 |
| Bowel function (4.4) | 91.7 (11.1) | 91.3 (9.0) | 91.6 (8.7) | 93.0 (7.9) | 0.170 |
| Bowel bother (5.0) | 95.4 (11.6) | 94.9 (9.8) | 94.7 (10.0) | 95.7 (9.7) | 0.755 |
| Sexual summary score (11.6) | 72.9 (20.6) | 65.8 (21.0) | 60.0 (23.2) | 56.2 (23.8) | <0.001 |
| Sexual function score (11.5) score | 66.1 (21.2) | 58.8 (20.3) | 53.0 (22.4) | 48.3 (24.0) | <0.001 |
| Sexual bother score (14.8) | 87.9 (24.1) | 81.1 (28.0) | 75.9 (30.8) | 74.0 (30.4) | <0.001 |
| Mental/physical health†(MID), n/N (%) | 142/189 (75) | 346/418 (83) | 403/532 (76) | 369/504 (73) | |
| Anxiety score (1.8)‡ | 5.5 (3.5) | 5.2 (3.5) | 4.8 (3.6) | 4.5 (3.3) | <0.001 |
| Depression score (1.3)‡ | 2.5 (2.8) | 2.4 (2.7) | 2.5 (2.5) | 2.4 (2.3) | 0.123 |
| Mental health score (3.8)§ | 51.9 (9.2) | 53.3 (7.3) | 53.9 (7.7) | 55.3 (6.5) | <0.001 |
| Physical health score (4.0)§ | 52.9 (7.6) | 51.6 (7.8) | 50.9 (8.0) | 50.3 (7.9) | <0.001 |
HADS, Hospital Anxiety and Depression Scale; MID, minimal clinically important difference; PROM, patient‐reported outcome measure; SF‐12, 12‐item short‐form health survey. Data are EPIC summary scores (sd), unless otherwise indicated. *Cuzick's test; MID 0.5 sd of baseline values with domains in bold where exceeded between youngest and oldest age groups. †Details of PROMs and their administration in Table 1 and Fig. 1; ‡HADS; §SF‐12;