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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Pain. 2016 Dec;157(12):2697–2708. doi: 10.1097/j.pain.0000000000000688

Fig. 5. Inactivation of lateral PB interfered with the ON-cell burst and OFF-cell pause in response to mechanical stimulation.

Fig. 5

A. ON-cells. Effect of lidocaine (4%, 200 nl) microinjected into the lateral PB on activity triggered during application of von Frey probes (26, 60 and 100 g, measured as total evoked spikes, n = 8). B. OFF-cells. Effect of lidocaine (4%, 200 nl) microinjected into the lateral PB on OFF-cell pause (measured as pause duration, n = 13). (PB injections were contralateral to the peripheral stimulus. Reported as geometric mean with 95% confidence limits, t-test for correlated means, *p < 0.05, **p < 0.01 compared to baseline.)

Statistical analysis.

ON-cells (n = 8): 26 g: t7 = 3.80, p = 0.0067; 60 g: t5 = 6.99, p = 0.0009 (two cells active at stimulus onset; 100 g: t7 = 3.77, p = 0.0069.

OFF-cells (n = 13): 26 g: t11 = 2.67, p = 0.022 (one cell silent at stimulus onset); 60 g: t11 = 3.17, p = 0.009 (one cell silent at stimulus onset); 100 g: t11 = 3.81, p = 0.0029 (one cell silent at stimulus onset).