Table 1. Clinical Characteristics of The Subjects.
| Variable | Total (n = 100) | Buerger disease No (n = 20) | Buerger disease Yes (n = 20) | P value | Atherosclerotic PAD No (n = 30) | Atherosclerotic PAD Yes (n = 30) | P value |
|---|---|---|---|---|---|---|---|
| Age, yr | 58.9 ± 14.1 | 43.0 ± 5.1 | 48.9 ± 14.4 | 0.09 | 65.7 ± 7.5 | 69.5 ± 7.8 | 0.06 |
| Sex, men/women | 79/21 | 19/1 | 18/2 | 0.54 | 20/10 | 22/8 | 0.57 |
| Body mass index, kg/m2 | 22.7 ± 3.2 | 22.7 ± 3.0 | 22.4 ± 3.1 | 0.75 | 23.7 ± 3.1 | 21.9 ± 3.2 | 0.03 |
| Systolic blood pressure, mmHg | 126.8 ± 19.8 | 118.1 ± 8.7 | 117.2 ± 16.7 | 0.84 | 130.9 ± 17.8 | 134.8 ± 24.1 | 0.49 |
| Diastolic blood pressure, mmHg | 74.5 ± 11.9 | 74.7 ± 7.4 | 70.2 ± 13.2 | 0.20 | 77.6 ± 11.5 | 74.3 ± 13.3 | 0.31 |
| Heart rate, bpm | 72.5 ± 12.1 | 71.3 ± 9.9 | 68.8 ± 11.9 | 0.48 | 69.3 ± 10.5 | 79.0 ± 13.0 | < 0.01 |
| Total cholesterol, mg/dL | 172.8 ± 31.4 | 178.4 ± 18.8 | 171.3 ± 34.8 | 0.57 | 175.0 ± 20.1 | 170.3 ± 39.3 | 0.61 |
| Triglycerides, mg/dL | 116.1 ± 58.5 | 81.4 ± 26.9 | 125.9 ± 67.1 | 0.07 | 127.7 ± 67.3 | 110.2 ± 47.7 | 0.28 |
| High-density lipoprotein cholesterol, mg/dL | 56.0 ± 17.2 | 63.1 ± 20.5 | 49.0 ± 11.3 | 0.03 | 57.9 ± 12.7 | 56.8 ± 21.8 | 0.83 |
| Low-density lipoprotein cholesterol, mg/dL | 98.0 ± 25.5 | 100.0 ± 20.4 | 102.4 ± 29.0 | 0.83 | 100.1 ± 19.6 | 92.2 ± 29.3 | 0.27 |
| Glucose, mg/dL | 116.4 ± 35.6 | 97.9 ± 16.6 | 101.1 ± 20.4 | 0.69 | 114.6 ± 21.8 | 133.9 ± 48.6 | 0.07 |
| Ankle-brachial index | 1.00 ± 0.24 | 1.20 ± 0.05 | 0.82 ± 0.25 | < 0.01 | 1.15 ± 0.07 | 0.83 ± 0.21 | < 0.01 |
| Rutherford class | |||||||
| 0, n (%) | 55 (55.0) | 20 (100.0) | 4 (20.0) | < 0.01 | 30 (100.0) | 1 (3.3) | < 0.01 |
| 1, n (%) | 5 (5.0) | 0 (0.0) | 4 (20.0) | 0.01 | 0 (0.0) | 1 (3.3) | 0.24 |
| 2, n (%) | 6 (6.0) | 0 (0.0) | 2 (10.0) | 0.09 | 0 (0.0) | 4 (13.3) | 0.02 |
| 3, n (%) | 7 (7.0) | 0 (0.0) | 1 (5.0) | 0.23 | 0 (0.0) | 6 (20.0) | < 0.01 |
| 4, n (%) | 5 (5.0) | 0 (0.0) | 1 (5.0) | 0.23 | 0 (0.0) | 4 (13.3) | 0.02 |
| 5, n (%) | 19 (19.0) | 0 (0.0) | 7 (35.0) | < 0.01 | 0 (0.0) | 12 (40.0) | < 0.01 |
| 6, n (%) | 3 (3.0) | 0 (0.0) | 1 (5.0) | 0.23 | 0 (0.0) | 2 (6.7) | 0.09 |
| Fontaine class | |||||||
| Stage I, n (%) | 55 (55.0) | 20 (100) | 4 (20.0) | < 0.01 | 3 (100) | 1 (3.3) | < 0.01 |
| Stage II, n (%) | 18 (18.0) | 0 (0) | 7 (35.0) | < 0.01 | 0 (0) | 11 (36.6) | < 0.01 |
| Stage III, n (%) | 5 (5.0) | 0 (0) | 1 (5.0) | 0.23 | 0 (0) | 4 (13.3) | 0.02 |
| Stage IV, n (%) | 22 (22.0) | 0 (0) | 8 (40.0) | < 0.01 | 0 (0) | 14 (46.7) | < 0.01 |
| Medical history, n (%) | |||||||
| Hypertension | 57 (57.0) | 1 (5.0) | 3 (15.0) | 0.28 | 25 (83.3) | 28 (93.3) | 0.22 |
| Dyslipidemia | 32 (32.0) | 2 (10.0) | 4 (20.0) | 0.37 | 15 (50.0) | 11 (36.7) | 0.30 |
| Diabetes mellitus | 38 (38.0) | 0 (0.0) | 1 (5.0) | 0.23 | 17 (56.7) | 20 (66.7) | 0.43 |
| Previous coronary heart disease | 22 (22.0) | 0 (0.0) | 0 (0.0) | ND | 7 (23.3) | 15 (50.0) | 0.03 |
| Smoker (current), % | 20 (20.0) | 4 (20.0) | 4 (20.0) | 1.0 | 8 (26.7) | 4 (13.3) | 0.19 |
| Smoker (past), % | 49 (49.0) | 8 (40.0) | 15 (75.0) | 0.02 | 10 (33.3) | 16 (53.3) | 0.12 |
| Medications, n (%) | |||||||
| Calcium-channel blockers | 24 (24.0) | 0 (0.0) | 1 (5.0) | 0.23 | 14 (46.7) | 9 (30.0) | 0.18 |
| Renin angiotensin system inhibitors | 34 (34.0) | 1 (5.0) | 1 (5.0) | 1.0 | 14 (46.7) | 18 (60.0) | 0.30 |
| Statins | 28 (28.0) | 2 (10.0) | 3 (15.0) | 0.63 | 15 (50.0) | 8 (26.7) | 0.06 |
| Medically treated diabetes | 29 (29.0) | 0 (0.0) | 0 (0.0) | ND | 14 (46.7) | 15 (50.0) | 0.80 |
PAD indicates peripheral arterial disease; ND, not detected.
All results are presented as means ± SD.