Table 1.
Half‐lives t 1/2 [min] of the detoxification of V‐type nerve agents and soman (GD; see Table S1 for concentrations) mediated by 2 a–e and 3 a–c (500 μm) in Tris‐HCl buffer (0.1 m, pH 7.40) at 37 °C. Measurements were performed at least three times and results are given as means ± the standard deviation.
| VX | CVX | VR | VM | n‐propyl‐VX | VE | i‐propyl‐VE | GD | |
|---|---|---|---|---|---|---|---|---|
| 2 a | 3.7±0.4 | 2.8±0.1 | 3.4±0.6 | 2.9±0.5 | 2.4±0.2 | 15.1±0.4 | 17.0±0.6 | 17.7±0.9 |
| 2 a [a] | 2.9±0.2 | 2.2±0.1 | 2.3±0.1 | n.d.[b] | n.d. | n.d. | n.d. | 5.8±0.2 |
| 2 b | 7.5±0.3 | 25.0±0.7 | 28.6±0.4 | 20.3±0.4 | 25.3±0.8 | 105.2±4.7 | 40.5±1.4 | 49.5±3.4 |
| 2 c | >120[c] | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | >120 |
| 2 d | >120 | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | >120 |
| 2 e | >120 | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | 91.2±6.8 |
| 3 a | >120 | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | 27.2±2.4 |
| 3 b | >120 | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | 46.6±2.8 |
| 3 c | >120 | >120 | >120 | >120 | >120 | >120 | >120 | 37.6±4.1 |
[a] Determined in phosphate buffer (0.1 m, pH 7.4). [b] Not determined. [c] Detoxification too slow to allow determination of a reliable half‐life.