Table 1.

The IC₅₀ values, ligand efficiencies (LE), and calculated and experimental Gibbs free energies of binding (ΔG) for the parent fragments and bis‐acylhydrazone inhibitors.

Inhibitors	IC50 [μm]	K i [μm]	ΔG [a] [kJ mol−1]	LE[a]
1	12.8±0.4	6±0.2	−30	0.27
2	14.5±0.5	7±0.2	−30	0.29
13	0.054±0.0005	0.0254±0.0002	−49	0.29
16	2.1±0.1	0.98±0.05	−34	0.25

[a] The Gibbs free energies of binding (ΔG) and the ligand efficiencies (LEs) were derived from the experimentally determined IC₅₀ values.