Table 2.
Linkage analysis results
| Phenotype | chr | LOD | n exp | Best SNP | Location |
|---|---|---|---|---|---|
| L peak width | 10 | 2.814 | 0.034 | rs10509410 | Intronic in PAPSS2 |
| R peak width | 16 | 2.339 | 0.146 | rs11861062 | Intergenic |
| M peak width | 2 | 1.118 | 0.208 | rs9288662 | Intronic in SP140 |
| L peak amplitude | 19 | 1.912 | 0.373 | rs1293703 | 3′in DPRX |
| M peak amplitude | 19 | 2.031 | 0.390 | rs269940 | Intronic in NLRP7 |
| R peak width | 8 | 1.996 | 0.414 | rs7015861 | Intronic in FAM91A1 |
| M peak amplitude | 18 | 1.827 | 0.661 | rs9945030 | Intronic in RP11‐47G4.2 |
| L peak amplitude | 16 | 1.631 | 0.738 | rs226042 | Intronic in CRYM |
| R peak width | 13 | 1.775 | 0.804 | rs7333894 | Intergenic |
| M peak frequency | 1 | 1.980 | 0.902 | rs11161750 | Intronic in COL24A1 |
| M peak width | 7 | 0.849 | 0.941 | rs10486813 | Intronic in SUGCT |
| L peak width | 18 | 1.802 | 0.949 | rs676603 | Intronic in AQP4‐AS1 |
Suggestive and significant linkages for the nine phenotypes, along with their chromosomal location (chr), significance based on 1001 permutations (n exp), name of best‐linked SNP and its location relative to genes. PAPSS2, 3′‐phosphoadenosine 5′‐phosphosulfate synthase 2; SP140, SP140 nuclear body protein; DPRX, divergent‐paired related homeobox; NLRP7, NLR family, pyrin domain‐containing 7; FAM91A1, family with sequence similarity 91 member A1; RP11‐47G4.2, gene RP11‐47G4.2; CRYM, crystallin mu; COL24A1, collagen, type XXIV, alpha 1; SUGCT, succinyl‐CoA,glutarate‐CoA transferase; AQP4‐AS1, AQP4 antisense RNA 1. L, left; M, middle; R, right parieto‐occipital region.