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. Author manuscript; available in PMC: 2016 Nov 17.
Published in final edited form as: Neuropsychol Rev. 2012 Apr 13;22(2):195–209. doi: 10.1007/s11065-012-9194-1

Fig. 7.

Fig. 7

Acetylcholinesterase inhibitors (AChE-Is) acutely infused into the hippocampus (a: 40 ng, ∂=0.97), medial septum (b: 5 μg, ∂=0.99) and medial frontal cortex (c: 1 μg, ∂=3.14) all significantly increased spontaneous alternation performance in PTD rats. However, infusion of the AChE-I physostigmine into the retrosplenial cortex did not improve cognitive outcome (d: 1 μg), although it increased ACh levels. *Significant (P<.01) difference between PF and PTD rats in the saline condition; ˆSignificant (P<.05) drug recovery in PTD rats. For comparisons across studies, Cohen’s effect size (∂) is reported. Dose response curves for all AChE-Is were conducted for behavior and ACh efflux. Only the maximum effective dose is shown for each drug condition