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. Author manuscript; available in PMC: 2017 Nov 15.
Published in final edited form as: J Immunol. 2016 Oct 19;197(10):3841–3849. doi: 10.4049/jimmunol.1600491

FIGURE 4.

FIGURE 4

Somatic hypermutation analysis of Malian young children and adult VH. (A) IgH sequence analysis for PBMCs acquired from 6 infants (3–11 months) and 9 toddlers (13–42 months) prior to the malaria transmission season (Pre) and 17 days following acute febrile malaria (Acute). Top panel. Average number of mutations in IgM-, IgG- and IgA-VH4-34. Bottom panel. Average number of mutations in IgM, IgG and IgA for all other VH genes. Statistical comparisons were by Mann Whitney U Test (ns = p value > 0.05; * = p value ≤ 0.05; ** = p value ≤ 0.01; *** = p value ≤ 0.001; **** = p value ≤ 0.0001). (B) Number of non-gap VH mutations for IgM and both IgG and IgA for naïve B cells, classical MBCs and atypical MBCs purified from the PBMCs acquired from four Malian adults for VH4-34 and all other VH.