. Author manuscript; available in PMC: 2016 Nov 17.

Published in final edited form as: Nat Rev Immunol. 2015 Dec 21;16(2):90–101. doi: 10.1038/nri.2015.1

Table 2.

Selected markers for resting, effector and memory T cell subsets^*

	Conventional T cells			Regulatory T cells

	Resting	Activated effector	Memory	Resting	Activated effector	Memory
Selected phenotypic markers	CD25^low	CD25^hi	CD25^low	CD25^hi	CD25 expression variable	CD25^hi
	CD44^low	CD44^hi	CD44^hi	CD44^hi		CD44^hi
	CD45RA^hi^‡	CD45RA expression variable^‡	CD45RA^low^‡	CD45RA^hi^‡	CD44^hi	CD45RA^low^‡
	CD45RO^low^‡		CD45RO^hi^‡	CD45RO^low^‡	CD45RA^low^‡	CD45RO^hi^‡
	CD69^low	CD45RO expression variable^‡	CD69 expression variable	CD69^low	CD45RO^hi‡	CD69 expression unknown
	L-selectin^hi	CD69^hi	L-selectin expression variable	L-selectin^hi	CD69^hi
	CD127^high	L-selectin^low		CD127^low	L-selectin^low
	Ki67^low	CD127^low		CTLA4^low	CD127^low	L-selectin^low
	BCL-2^hi	Ki67^hi	CD127^hi	ICOS^low	CTLA4^hi	CD127^hi^§
		BCL-2^low	CD27^hi	HLA-DR^low‡	ICOS^hi	CTLA-4^hi
		KLRG1^hi	Ki67^low	Ki67^low	HLA-DR^hi‡	ICOS^hi
			BCL-2^hi	BCL-2^hi	Ki67^hi	HLA-DRexpression not defined
					BCL-2^low
					KLRG1^hi	CD27^hi
						Ki67^low
						BCL-2^hi
						KLRG1 expression not defined

Chemokine receptors	CCR7^hi	Several, including CCR3, CCR6, CCR8 and CXCR3	Variable levels of CCR7	CCR7^hi	CCR7^low	CCR7^low

Transcription factors	FOXP3^low KLF2	FOXP3 expression variable^‡ Several, including T-bet (T_H1 cell-associated), GATA3 (T_H 2 cell-associated), RORγ (T_H17 cell-associated) and BCL-6 (T_FH cell-associated)^\|\|	FOXP3^low	FOXP3^hi	FOXP3^high Several others, including T-bet and IRF4	FOXP3^hi
Transcription factors	FOXP3^low KLF2		FOXP3^low	FOXP3^hi	FOXP3^high Several others, including T-bet and IRF4

BCL, B cell lymphoma; CCR CC-chemokine receptor; CTLA4, cytotoxic T lymphocyte antigen 4; CXCR, CXC-chemokine receptor; FOXP3, forkhead box P3; GATA3, GATA-binding factor 3; ICOS, inducible T cell co-stimulator; IRF4, IFN-regulatory factor 4; KLF2, Krueppel-like factor 2; KLRG1, killer cell lectin-like receptor subfamily G member 1; RORγ, retinoic acid receptor-related orphan receptor-γ; T_FH, T follicular helper; T_H, T helper.

Table compiled from REFS 1,7,11–16,19,29, 30,40,64,65,74,103–106.

^‡

Human only.

^§

Shown only in mouse skin.

^||

CD4⁺ T cells only.