Table 4.
Odds ratio (OR) and 95% confidence interval (95% CI) for the association between anti‐TNF treatment biological response and polymorphisms for polymorphisms investigated in more than one individual cohort using biological response criteria
| Disease | Gene | rs number | OR (95% CI) | MAF | Model | Criteriaa | Response groups | Reference |
|---|---|---|---|---|---|---|---|---|
| Antibody‐dependent immune responses | ||||||||
| CD | FCGR3A | rs396991 | 1.43 (1.27–1.61)a | T | TT vs. TG or GG | ΔCRP | R and P vs. N | Louis et al.29 |
| CD | >1 | T | TT vs. TG or GG | ΔCRP | R vs. N | Louis et al.34 | ||
| CD | >1 | T | TT vs. TG or GG | ΔCRP | R vs. N | Moroi et al.35 | ||
no.a., No association; R, Responder; N, nonresponder; P, partial responder; IBDQ, IBD questionaire; CRP, C‐reactive protein; MAF, minimal allele frequency.
a
For response criteria please refer to Table 1.